S.No Name of the intermediate CAS. No API
1. (R)-Boc-β-Iodo-Ala-Ome 93267-04-0 Eluxadoline
4-Iodo-3,5-dimethyl benzonitrile 1227311-09-2
2. Tert-butyl 3-(3-methylpyridin-2-yl)benzoate 1083057-12-8 VX-809, Lumacaftor
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl ester 1083057-14-0
1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropane carboxylic acid 862574-88-7
3. Benzofuran-6-carboxylic acid 77095-51-3 Lifitegrast
5,7-dichloro-2-BOC-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 851784-82-2
Methyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride 851785-21-2
Benzyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate 1194550-59-8
L-Phenylalanine, N-[(5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3-(methylsulfonyl)-phenylmethyl ester hydrochloride 1194550-65-6
4. Ethyl 4-(2-chloropyrimidin-4-yl)benzoate 499195-60-7 Momelotinib Dihydrochloride
Ethyl 4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate 1056634-62-8
Momelotinib 1056634-68-4
5. Abemaciclib mesylate 1231930-82-7 Abemaciclib
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5
2-Bromopyridine-5-carbaldehyde 149806-06-4
6-(2-chloro-5-fluoro-pyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo imidazole 1231930-42-9
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1231930-33-8
6. N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide 1383385-64-5 Acalabrutinib, ACP-196
(2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester 1420478-88-1
7. 4-cyclopropylnaphthalen-1-amine hydrochloride 1533519-92-4 RDEA 594, Lesinurad
1-cyclopropyl-4-isothiocyanatonaphthalene 878671-95-5
5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-Triazole-3-thione 878671-96-6
4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4
Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate 1533519-85-5
8. 2,4,5-Trifluorophenylacetic acid 209995-38-0 Sitagliptin phosphate monohydrate
Meldrum acid 2033-24-1
3-(Trifluoromethyl)-5,6,7,8,-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine HCl 762240-92-6
9. 3-Amino-1-adamantanol; 3-Amino-1-hydroxyadamantane 702-82-9 Vildagliptin
L-Prolinamide 7531-52-4
(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile 207557-35-5
10. Tetrabenzyl voglibose 115250-39-0 Voglibose
11. N-Boc-4-oxo-L-proline 84348-37-8 Teneligliptin Hydrobromide
(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine 401566-79-8
12. (R)-3-BOC-Aminopiperidine 309956-78-3 Linagliptin
2-(chloro methyl)-4-methyl quinazoline 109113-72-6
8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione 666816-98-4
13. (R)-3-piperidinamine di-HCl 334618-23-4 Alogliptin Benzoate
6-Chloro-3-methyluracil 4318-56-3
2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile 865758-96-9
14. Boc-3-Hydroxy-1-adamantyl-D-glycine 361442-00-4 Saxagliptin HCl
(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester 361440-67-7
15. 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9 Canagliflozin Hemihydrate
16. 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
17. 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester 112811-71-9 Moxifloxacin Hydrochloride
18. (S,S)-2,8-diazabicyclo(4,3,0)nonane 151213-42-2
19. 4-Amino-5-imidazolecarboxamide hydrochloride 72-40-2 Temozolomide
20. 2-Deoxy-D-Ribose 553-67-5 Decitabine
21. 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 145783-14-8 Ticagrelor
4,6-Dichloro-2-(PropylSulfanyl)-Pyrimidin-5-Amine 145783-15-9
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium (2R)-hydroxy(phenyl) ethanoate 376608-71-8
(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-amine HCl 1156491-10-9
2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4- yloxy)ethanol L-tataric acid 376608-65-0
22. 4-octylphenethyl methane sulfonate 162358-06-7 Fingolimod HCl
1-(2-iodoethyl)-4-octylbenzene 162358-07-8
Diethyl 2-acetamido-2-(4-octylphenethyl)malonate 162358-08-9
N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide 249289-10-9
2-Acetoxymethyl-2-acetylamino-4-(4-octylphenyl)acetic acid butyl ester 162358-09-0
Fingolimod Base 162359-55-9
23. 4-Cloromethyl-5-methyl-1,3-dioxol-2-one (DMDO-Cl) 80841-78-7 Olmesartan Medoxomil
24. Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate 144689-93-0
25. 7-(4-Chlorobutoxy)-1H-quinolin-2-one 913613-82-8 Brexpiprazole
1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride 913614-18-3
1-(Benzo[b]thiophen-4-yl)piperazine 846038-18-4
26. Methyl 2-bromomethyl-3-nitrobenzoate 98475-07-1 Lenalidomide
3-Aminopiperidine-2,6-dione hydrochloride (Pomalidomide intermediate as well) 24666-56-6
27. 4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one 91526-18-0 Azilsartan
1-(2-cyanobiphenyl-4-yl-methyl)- 2-ethoxybenzimidazole-7-carboxylic acid ethyl ester 139481-44-0
28. R(+)-a-phenylethylamine, R(+)-a-methylbenzylamine 3886-69-9 Pregabalin
S-(-)-a-phenylethylamine, S(-)-a-methylbenzylamine 2627-86-3
Glutaric anhydride 108-55-4
3,4-Difluoronitrobenzene 369-34-6
3,4-Difluoroaniline 3863-11-4
5-Fluoro-2-oxindole 56341-41-4
1-Iodo-4-nitrobenzene 636-98-6
Diisopropyl azodicarboxylate (DIAD) 2446-83-5
29. 1-Methyl-Indozole-3-Carboxylic Acid / 1-MICA 50890-83-0 Granisetron intermediates
Endo-9-methyl-9-azabicyclo[3,3,1] -nonan-3 –amine / EMANA 76272-56-5
Endo-9-methyl-9-azabicyclo[3,3,1] -nonan-3 -amine •2HCl / EMANA •2HCl 135906-03-5
30. 2-[(4-Chlorophenyl)acetyl]benzoic acid 53242-76-5 Azelastine intermediates
1-Methylhexahydroazepin-4-one hydrochloride 19869-42-2
31. 7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-

heptanoic Acid tert-Butyl Ester / Atorvastatin tert-Butyl Ester

 134395-00-9 Atorvastatin intermediates
(4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-

[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate / L-1

 125971-95-1
(4R-Cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate / Ats-8 125971-94-0
32. (+)-(3r, 5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-6(E)-Heptenate / Rosuvastatin tert butyl ester 355806-00-7 Rosuvastatin intermediates
tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate / D5 154026-95-6
4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol / Z-7 147118-36-3
33. 5-(4-Chlorobutyl)-1-Cyclohexyl-1H-Tetrazole 73963-42-5 Cilostazol intermediates
3,4-dihydro-6-hydroxyquinolin-2(1H)-one 54197-66-9
34. 7,10-Dimethoxy-10-DAB III 183133-94-0 Cabazitaxel intermediates
35. 4-Bromo-7-methoxy-1,3-benzodioxole-5-carboxylic acid methyl ester 81474-46-6 Bifendate intermediates
36. 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-

oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone / ZT-6

 272778-12-8 Ezetimibe intermediates
(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-

(phenylmethoxy)phenyl]-2-azetidinone / E7

 163222-32-0
37. (S)-1,2-diaminopropane dihydrochloride 19777-66-3 Dexrazoxane intermediates
38. 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6 Sitagliptin intermediates
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8
39. (S,S)-2,8 - Diazabicyclo (4,3,0) Nonane / Side chain 151213-40-0 Moxifloxacin intermediates
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3 quinolinecarboxylic acid / Main chain 112811-72-0
40. Methyl-2-(2,3-diclorobenzylidene)acetoacetate 74073-22-6 Felodipine intermediates
41. Phthaloyl Amlodipine 88150-62-3 Amlodipine intermediates
42. (3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one / 4-AA 76855-69-1 Carbapenem Basic KSM
43. Diphenyl chlorophosphate / DPCP 2524-64-3
44. 2,2-Dimethyl-1,3-dioxane-4,6-dione / Meldrum's acid 2033-24-1
45. p-Nitrobenzyl chloroformate 4457-32-3
46. (2S,4S)-2-Dimethylaminocarboxyl-4-mercapto-1-p-nitrobenzyloxycarbonyl-pyrrolidine / 2S CIS [96034-64-9] Meropenem intermediates
PNB(4R,5S,6S)-3-(Diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1 azabicyclo[3,2,0]hept-2-ene-2-carboxylate / MAP [90776-59-3]
47. 1-Naphthyl acetonitrile 132-75-2 Naphazoline intermediates
48. N-[1-(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine 82717-96-2 Enalapril intermediates
49. 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2 Baricitinib intermediates
tert-Butyl 3-(cyanomethylene)azetidine-1-carboxylate 1153949-11-1
1-Boc-pyrazole-4-boronic acid pinacol ester 552846-17-0
Ethanesulfonyl Chloride 594-44-5
50. 7-Phenyl acetamido-3-Hydroxy-3-Cephem-4-Carboxylic acid Diphenylmethyl ester / GHYH 54639-48-4 Ceftizoxime intermediates
7-Amino-3-nor-3-cephem-4-carboxylic acid / 7-ANCA 36923-17-8
51. 5-Mercapto-1H-tetrazole-1-acetic acid / MTAA

57658-36-3

 Ceforanide intermediates
2-Aminnomethyl phenyl acetic acid/AMPAA

40851-65-8
52. 2-Mercapto-5-methyl-1,3,4-thiadiazole / MMTD 29490-19-5 Cefazolin intermediates
1H-Tetrazol yl-1-acetic aid /TAA 21732-17-2
53. (Z)-2-(5-Amino-1,2,4-Thiadiazol-3-yl)-2-Ethoxyiminoacetic Acid / ATDE 75028-24-9 Ceftaroline intermediates
4-(4-Pyridyl)thiazole-2-thiol / PTT 77168-63-9
54. Boron Trifluoride Acetonitrile Complex 420-16-6 Fine chemicals
Boron Trifluoride DiMethyl Phthalate Complex N/A
Boron Trifluoride 7637-07-2